Anti-NFATC2 (aa 812-921) polyclonal antibody

Species Reactivity

Human

Immunogen

NFATC2 (NP_036472, 812 a.a. ~ 921 a.a) partial recombinant protein with GST tag. The sequence is HYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATS QRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTRLSWIQNIL

Conjugate

Alternative Names

NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; NFAT1; NFATP; nuclear factor of activated T-cells, cytoplasmic 2; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor NFAT1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Pathway

Axon guidance; B cell receptor signaling pathway; Calcium signaling in the CD4+ TCR pathway; FCERI mediated Ca+2 mobilization