Anti-NFASC (aa 661-758) polyclonal antibody

Species Reactivity

Human

Immunogen

NFASC (NP_001005388, 661 a.a. ~ 758 a.a) partial recombinant protein with GST tag. The sequence is KDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTN RLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNS

Conjugate

Alternative Names

NFASC; neurofascin; NF; NRCAML; neurofascin homolog;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Pathway

Axon guidance; Developmental Biology; L1CAM interactions;