NEU2 (NP_005374, 180 a.a. ~ 268 a.a) partial recombinant protein with GST tag. The sequence is AYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSH LRARVQAQSTNDGLDFQESQLVKKLVEPP
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.
Pathway
Asparagine N-linked glycosylation; Glycosphingolipid metabolism; Metabolism of lipids and lipoproteins; Other glycan degradation.
Citations
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