COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription. COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogeneis.
Pathway
Abortive elongation of HIV-1 transcript in the absence of Tat; Disease; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of RNA Pol II elongation complex; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Gene Expression;
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