Anti-NEIL3 monoclonal antibody, clone 3738D2c

Antibody Isotype

IgG1

Clone

3738D2c

Species Reactivity

Human

Immunogen

Recombinant fragment (Human)

Conjugate

Alternative Names

NEIL3; nei endonuclease VIII-like 3 (E. coli); endonuclease 8-like 3; FLJ10858; FPG2; hFPG2; hNEI3; nei-like protein 3; DNA glycosylase FPG2; DNA glycosylase hFPG2; endonuclease VIII-like 3; DNA glycosylase/AP lyase Neil3; FGP2; NEI3;

Entrez Gene ID

UniProt ID

Antigen Description

Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected.

Pathway

Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;