Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human NEIL2 aa 200-300. The exact sequence is proprietary.Database link: Q969S2
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/10000 - 1/50000; Flow Cyt: 1/10; IP: 1/40;
Target
Alternative Names
NEIL2; nei endonuclease VIII-like 2 (E. coli); nei like 2 (E. coli); endonuclease 8-like 2; FLJ31644; MGC2832; MGC4505; NEH2; nei like 2; nei homolog 2; nei-like protein 2; endonuclease VIII-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimi
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.
Pathway
Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem.
Citations
Publication ()
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