The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I.
Pathway
Alzheimers disease; Electron Transport Chain; Huntingtons disease; Metabolism; NADH dehydrogenase (ubiquinone) 1 beta subcomplex; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinsons disease; Respiratory electron transport; Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport.
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