Anti-NDUFA13 monoclonal antibody, clone 7F2CI8

Antibody Isotype

IgG2b

Clone

7F2CI8

Species Reactivity

Mouse; Rat; Cow; Human

Immunogen

Recombinant full length protein Human GRIM19.

Conjugate

Application Notes

WB: 1 μg/ml; ICC/IF: 1 μg/ml; ELISA: 8 μg/ml; In-Cell ELISA: 0.8 μg/well; Flow Cyt: 1 μg/ml

Alternative Names

NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; B16.6; CDA016; CGI 39; complex I B16.6 subunit; GRIM 19; GRIM19; CI-B16.6; complex I-B16.6; cell death-regulatory protein GRIM1

Entrez Gene ID

UniProt ID

Antigen Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem;