Anti-NDST1 (aa 819-849) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 819-849 of Human NDST1 (NP_001534.1).

Conjugate

Application Notes

WB: 1/100 - 1/500; IHC-P: 1/10 - 1/50.

Alternative Names

NDST1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; HSST; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NST1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1

Entrez Gene ID

UniProt ID

Antigen Description

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.

Pathway

Glycosaminoglycan biosynthesis - heparan sulfate; Glycosaminoglycan biosynthesis, heparan sulfate backbone; Metabolic pathways; heparan sulfate biosynthesis;