Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Fulmer-Smentek, SB; Francke, U; et al. Association of acetylated histones with paternally expressed genes in the Prader-Willi deletion region. HUMAN MOLECULAR GENETICS 10:645-652(2001).
Bauer, K; Zemlin, M; et al. Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed to environmental antigens. JOURNAL OF IMMUNOLOGY 169:1349-1356(2002).
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