Anti-NDE1 (aa 1-163) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant protein fragment corresponding to a region within amino acids 1 and 163 of Human NDE1.

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

NDE1; nudE nuclear distribution E homolog 1 (A. nidulans); nudE nuclear distribution gene E homolog 1 (A. nidulans); nuclear distribution protein nudE homolog 1; FLJ20101; NUDE; nudE nuclear distribution gene E homolog 1; LIS1-interacting protein NUDE1, r

Entrez Gene ID

UniProt ID

Antigen Description

Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle.

Pathway

Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; DNA Replication; G2/M Transition; Loss of Nlp from mitotic centrosomes; Loss of proteins required for interphase microtubule organization??from the centrosome