Anti-NDC1 (aa 323-372) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within the internal sequence amino acids 323-372 (PPIIKYLALQ DLMLLSQYSP SRRQEVFSLS QPGGHPHNWT AISRECLNLL) of Human NDC1, NP_060557.

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

NDC1; NDC1 transmembrane nucleoporin; NET3; TMEM48; nucleoporin NDC1; transmembrane protein 48; nuclear division cycle 1 homolog;

Entrez Gene ID

UniProt ID

Antigen Description

NDC1 is a component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. NDC1 is required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. NDC1 colocalizes with p62 (NUP62) on the nuclear envelope at the nuclear rim. The protein has 6 transmembrane domains and several putative phosphorylation sites.

Pathway

Nuclear pore complex; RNA transport;