Anti-NCOA4 (aa 505-614) polyclonal antibody

Species Reactivity

Human

Immunogen

NCOA4 (NP_005428, 505 a.a. ~ 614 a.a) partial recombinant protein with GST tag. The sequence is EGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKK AQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM

Conjugate

Alternative Names

NCOA4; nuclear receptor coactivator 4; RFG; ELE1; PTC3; ARA70; NCoA-4; ret fused; 70 kDa AR-activator; RET-activating gene ELE1; 70 kDa androgen receptor coactivator; androgen receptor-associated protein of 70 kDa;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.

Pathway

Androgen receptor signaling pathway; Diurnally regulated genes with circadian orthologs; Thyroid cancer;