Anti-NCOA3 monoclonal antibody, clone FQS5485(4)

Antibody Isotype

IgG

Clone

FQS5485(4)

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues on the C terminus of Human KAT13B/ AIB1 (UniProt ID: Q9Y6Q9).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; ICC/IF: 1/50 - 1/100; Flow Cyt: 1/100 - 1/500;

Alternative Names

NCOA3; nuclear receptor coactivator 3; ACTR; AIB1; bHLHe42; CAGH16; KAT13B; p/CIP; RAC3; receptor associated coactivator 3; SRC 3; SRC3; thyroid hormone receptor activator molecule 1; TNRC16; TRAM 1; CBP-interacting protein; receptor-associated coactivato

Entrez Gene ID

UniProt ID

Antigen Description

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Developmental Biology, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem;