Anti-H2-EA-PS monoclonal antibody, clone D4B4-Ep4

Antibody Isotype

IgG3, κ

Clone

D4B4-Ep4

Species Reactivity

Mouse; Rat

Immunogen

The details of the immunogen for this antibody are not available.

Conjugate

Application Notes

Flow Cyt: 1.0μg/10⁶ cells.

Alternative Names

H2-EA-PS; histocompatibility 2, class II antigen E alpha, pseudogene; AI323765; E alpha f; H 2 class II histocompatibility antigen E D alpha chain; H 2Ea; H2 class II histocompatibility antigen E D alpha chain; H2 Ea; H2 Ea histocompatibility 2 class II a

Entrez Gene ID

Antigen Description

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Pathway

Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem