Synthetic peptide within Human Mesp1 aa 45-75 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9BRJ9
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/10 - 1/50; WB: 1/100 - 1/500.
Target
Alternative Names
MESP1; mesoderm posterior 1 homolog (mouse); mesoderm posterior protein 1; bHLHc5; MGC10676; class C basic helix-loop-helix protein 5;
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
Citations
Publication ()
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References
Cardiac regeneration using human embryonic stem cells: producing cells for future therapy
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. Because of their ability to differentiate into any cell type in the body, hESCs offer a novel therapeutic paradigm for myocardial repair by,furnishing a supply of cardiomyocytes (CMs) that would ultimately restore normal myocardial function when delivered to the damaged heart. Spontaneous CM differentiation of hESCs is an inefficient process that yields very low numbers of CMs. In addition, it is not clear that fully differentiated CMs provide the benefits sought from cell transplantation. The need for new methods of directed differentiation of hESCs into functional CMs and cardiac progenitors has led to an explosion of research utilizing chemical, genetic, epigenetic and lineage selection strategies to direct cardiac differentiation and enrich populations of cardiac cells for therapeutic use. Here, we review these approaches and highlight their increasingly important roles in stem cell biology and cardiac regenerative medicine.
Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites (vol 132, pg 787, 2005)
COA
Publication 
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