Anti-MYOF (aa 655-754) polyclonal antibody

Species Reactivity

Human

Immunogen

FER1L3 (NP_038479, 655 a.a. ~ 754 a.a) partial recombinant protein with GST tag. The sequence is DAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKAN VTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEI

Conjugate

Alternative Names

MYOF; myoferlin; FER1L3; fer-1-like protein 3; fer-1-like 3, myoferlin; fer-1-like family member 3;

Entrez Gene ID

UniProt ID

Antigen Description

Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.