Anti-MYO7A monoclonal antibody, clone 93 (CHO/05/5593)

Antibody Isotype

IgG1

Clone

93 (CHO/05/5593)

Species Reactivity

Rabbit; Human

Immunogen

Native myosin heavy chain from muscle

Conjugate

Alternative Names

MYO7A; myosin VIIA; DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA; unconventional myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))

Entrez Gene ID

UniProt ID

Antigen Description

Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba.

Pathway

Disease; Diseases associated with visual transduction; Signal Transduction; The canonical retinoid cycle in rods (twilight vision); Visual phototransduction