Synthetic peptide within Human MYO6 aa 1173-1203 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9UM54
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
Pathway
Gap junction degradation; Gap junction trafficking; Gap junction trafficking and regulation; Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity; Membrane Trafficking; Neuronal System; Neurotransmitter Receptor Binding And Downstream T
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