Specifications
Immunogen
Recombinant protein corresponding to amino acids of human MYH6. The sequence is QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA KVEKLRSDLSRELEEISERLEEA
Applications
Application Notes
WB: 1:250-1:500; IF: 1-4 μg/mL. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
MYH6; myosin, heavy chain 6, cardiac muscle, alpha; ASD3; MYHC; SSS3; CMH14; MYHCA; CMD1EE; alpha-MHC; myosin-6; myHC-alpha; myosin heavy chain 6; myosin heavy chain, cardiac muscle alpha isoform; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardio
Product Background
Antigen Description
Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.
Pathway
Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM); Muscle contraction
Citations
Publication ()
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COA
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