May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
Pathway
Metabolism of proteins; O-linked glycosylation of mucins; Post-translational protein modification; Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met); Termination of O-glycan biosynthesis;
Citations
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