Anti-MTHFS (aa 104-203) polyclonal antibody

Species Reactivity

Human

Immunogen

MTHFS (NP_006432, 104 a.a. ~ 203 a.a) partial recombinant protein with GST tag. The sequence is LPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQH QEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA

Conjugate

Alternative Names

MTHFS; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); HsT19268; 5-formyltetrahydrofolate cyclo-ligase; methenyl-THF synthetase;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.

Pathway

One Carbon Metabolism; One carbon pool by folate;