Anti-MTA2 monoclonal antibody, clone NUB3-387

Antibody Isotype

IgG1

Clone

NUB3-387

Species Reactivity

Mouse; Rat; Hamster; Cow; Dog; Human; Monkey

Immunogen

Synthetic peptide: RRAARRPNLPLKVKPT conjugated to KLH, corresponding to amino acids 626-641 of Human MTA2

Conjugate

Application Notes

WB: 1 - 2 μg/ml;

Alternative Names

MTA2; metastasis associated 1 family, member 2; metastasis associated gene family, member 2 , MTA1L1; metastasis-associated protein MTA2; MTA1 L1; MTA1-L1 protein; metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis -associated gen

Entrez Gene ID

UniProt ID

Antigen Description

The p53 tumor suppressor gene integrates numerous signals that control cell life and death. There are several proteins that are involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and MTA2. The transcriptional activity of p53 is modulated by protein stability and acetylation. MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NuRD) complex. MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. MTA2 is ubiquitously expressed in human tissues.

Pathway

EGFR1 Signaling Pathway, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem;