Anti-MRPS11 monoclonal antibody, clone 4G2

Antibody Isotype

IgG2a

Clone

4G2

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human MRPS11 aa 1-194. Produced in E.coli (NP_073750).Sequence: MQAVRNAGSRFLRSWTWPQTAGRVVARTPAGTICTGARQLQDAAAKQKVE QNAAPSHTKFSIYPPIPGEESSLRWAGKKFEEIPIAHIKASHNNTQIQVV SASNEPLAFASCGTEGFRNAKKGTGIAAQTAGIAAAARAK

Conjugate

Application Notes

WB: 1/2000;

Alternative Names

MRPS11; mitochondrial ribosomal protein S11; 28S ribosomal protein S11, mitochondrial; cervical cancer proto oncogene 2; FLJ22512; FLJ23406; HCC 2; S11mt; MRP-S11; cervical cancer proto-oncogene 2 protein; HCC-2;

Entrez Gene ID

UniProt ID

Antigen Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encode different protein isoforms.