Anti-MRPL57 (aa 25-76) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

antigen sequence: RFVSLRAKQN MIRRLEIEAE NHYWLSMPYM TREQERGHAA VRRREAFEAI KA, corresponding to internal sequence amino acids 25-76 of Human MRP63.

Conjugate

Application Notes

IHC-P: 1/50 - 1/200. WB: 1/250 - 1/500.

Alternative Names

MRPL57; mitochondrial ribosomal protein L57; MRP63; bMRP63; ribosomal protein 63, mitochondrial; hMRP63; mitochondrial ribosomal protein 63; mitochondrial ribosomal protein bMRP63;

Entrez Gene ID

UniProt ID

Antigen Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y.