MPHOSPH8 (M-phase phosphoprotein 8) is a protein-coding gene. Diseases associated with MPHOSPH8 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include methylated histone residue binding. Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.
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