Specifications
Species Reactivity
Mouse; Human
Applications
Application Notes
IHC-P: 1/500 - 1/2000; WB: 1/1000 - 1/10000; IP: 2-5 μg/mg.
Target
Alternative Names
MOV10; Mov10, Moloney leukemia virus 10, homolog (mouse); Mov10 (Moloney leukemia virus 10, mouse) homolog; putative helicase MOV-10; fSAP113; functional spliceosome associated protein 113; gb110; MGC2948; moloney leukemia virus 10 protein; functional spl
Product Background
Antigen Description
MOV10 may be an helicase with an important function in development and/or control of cell proliferation. RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs). They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs. Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA. Ago1- and Ago2-containing complexes have been purified from human cells, resulting in the discovery of novel factors such as the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required to mediate miRNA-guided mRNA cleavage.
Pathway
Pre-NOTCH Expression and Processing, organism-specific biosystem; Pre-NOTCH Transcription and Translation, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem.
Citations
Publication ()
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COA
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