Specifications
Immunogen
Antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human MORF4.
Target
Alternative Names
MORF4; mortality factor 4; CSR; SEN; CSRB; SEN1
Product Background
Antigen Description
Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM, Apr 2004]
Pathway
Chromatin modifying enzymes; Chromatin organization; HATs acetylate histones
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Tominaga, K; Pereira-Smith, OM; et al. The genomic organization, promoter position and expression profile of the mouse MRG15 gene. GENE 294:215-224(2002).
Tominaga, K; Kirtane, B; et al. Functional abalysis of null versus heterozygous and wild type mice of MRG15, a family member of MORF4, a cell senenscience inducing gene. GERONTOLOGIST 43:4-4(2003).
COA
Certificate of Analysis
