Anti-MOB1B monoclonal antibody (DCABH-828)

Mouse anti-Human MOB1B monoclonal antibody for WB, IHC-P Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4H0
Species Reactivity
Human
Immunogen
Recombinant full length Human MOB4A protein (NP_775739).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500; IHC-P: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MOB1B; MOB kinase activator 1B; MOB1 Mps One Binder homolog B (yeast) , MOB1, Mps One Binder kinase activator like 1A (yeast) , MOBKL1A; MOB4A; Mob4A protein; mob1A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MOB1B (MOB Kinase Activator 1B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include kinase binding and kinase activator activity. An important paralog of this gene is MOB1A. The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene. The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. The function about MOB1B antigen include kinase activator activity; kinase binding; metal ion binding; protein binding.
Pathway
Signal Transduction, organism-specific biosystem; Signaling by Hippo, organism-specific biosystem.

Citations


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References


Bao, YJ; Sumita, K; et al. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. GENES TO CELLS 14:1369-1381(2009).
Bao, YJ; Sumita, K; et al. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. GENES TO CELLS 14:1369-1381(2009).

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