Rabbit Anti-Human MNT (a.a. 233-582) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human MNT protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 233-582 aa of BC117563

Conjugate

Application Notes

WB: 1:500-1:1000
IF/ICC: 1:20-1:200

General Notes

This product (Catalog No. DPABH-23839) is a rabbit-derived polyclonal antibody raised against human MNT, targeting the amino acid region 233–582 of the protein. It has been affinity purified by Protein A. Mnt (Max binding protein), also known as MAD6, ROX, bHLHd3 (class D basic helix-loop-helix protein 3) or MXD6, is a 582 amino acid nuclear protein that forms a complex with Max (Myc-associated factor X) to repress transcription. Mnt contains one basic helix-loop-helix (bHLH) domain and is encoded by a gene that maps to human chromosome 17p13.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
DPABH-23839 is suitable for use in Western blot (WB) (1:500–1:1,000), IF/ICC (1:20–1:200) applications.
DPABH-23839 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

bHLHd3; Class D basic helix-loop-helix protein 3; MAD6; MAX binding protein; Max binding protein MNT

Entrez Gene ID

UniProt ID