Synthetic peptide within Human Multimerin 2 aa 767-797 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9H8L6
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/10 - 1/50; WB: 1/100 - 1/500;
Target
Alternative Names
MMRN2; multimerin 2; EMILIN3; EMILIN-3; ENDOGLYX-1; multimerin-2; endoGlyx-1 p125/p140 subunit; EMILIN-like protein EndoGlyx-1; elastin microfibril interfacer 3; elastin microfibril interface located protein 3;
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.
Citations
Publication ()
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