General Notes
This product (Catalog No. DPABH-05583) is a rabbit-derived polyclonal antibody raised against human MMACHC, targeting the amino acid region 1–225 of the protein. This antibody exhibits cross-reactivity with Human MMACHC from mouse and rat. It has been affinity purified by Protein A. MMACHC, also named as CblC, is located on chromosome 1 and comprises four coding exons. Human MMACHC catalyzes the reductive decyanation of cyanocobalamin and may serve as a trafficking chaperone for intracellular cobalamin. It also catalyzes the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. NMACHC binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives.
DPABH-05583 is suitable for use in Western blot (WB) (1:500–1:1,000), IHC (1:50–1:500) applications.
DPABH-05583 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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