Anti-MLXIPL monoclonal antibody, clone 6C3

Antibody Isotype

IgG2a

Clone

6C3

Species Reactivity

Human

Immunogen

MLXIPL (NP_116569.1, 603 a.a. ~ 700 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

MLXIPL; MLX interacting protein-like; WBSCR14, Williams Beuren syndrome chromosome region 14; carbohydrate-responsive element-binding protein; bHLHd14; carbohydrate response element binding protein; CHREBP; MIO; MONDOB; WS bHLH; Mlx interactor; MLX-intera

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.

Pathway

AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem; ChREBP activates metabolic gene expression, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; PKA-mediated phosphorylation of key metabolic factors, organism-specific biosystem; PP2A-mediated dephosphorylation of key metabolic factors, organism-specific biosystem.