Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders.
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like; Gastrin-CREB signalling pathway via PKC and MAPK; Neuroactive ligand-receptor interaction; Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR;
Citations
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