Anti-MICAL1 monoclonal antibody (DCABH-879)

Mouse anti-Human MICAL1 monoclonal antibody for WB, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2D3
Species Reactivity
Human
Immunogen
Recombinant full length Human MICAL1 produced in HEK293T cells (NP_073602).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1; NEDD9 interacting protein with calponin homology and LIM domains , NICAL; protein-methionine sulfoxide oxidase MICAL1; DKFZp434B1517; FLJ11937
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MICAL1 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1) is a Protein Coding gene. Diseases associated with MICAL1 include anthracosilicosis. GO annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is SMTNL2. This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants.
Antigen Description
May be a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene. 0The function about MICAL1 antigen include SH3 domain binding; metal ion binding; monooxygenase activity; protein binding; zinc ion binding.

Citations


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References


Ben Cheikh, BOA; Baulac, S; et al. A locus for bilateral occipital polymicrogyria maps to chromosome 6q16-q22. NEUROGENETICS 10:35-42(2009).
Lee, BC; Peterfi, Z; et al. MsrB1 and MICALs Regulate Actin Assembly and Macrophage Function via Reversible Stereoselective Methionine Oxidation. MOLECULAR CELL 51:397-404(2013).

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