Anti-MHC Class I H2 Kb + Db monoclonal antibody, clone 6152.27.2 [Biotin]

Antibody Isotype

IgG2a

Clone

6152.27.2

Species Reactivity

Mouse

Immunogen

Mouse CBA/J bm12 thymus,lymph node and spleen cells.

Conjugate

Application Notes

Flow Cyt: 0.1μg/10⁶ cells.

Alternative Names

H2-D1; histocompatibility 2, D region locus 1; H-2 class I histocompatibility antigen, L-D alpha chain; Q5k protein; MHC class I H-2Dp; MHC H2-D-q alpha-chain; MHC class I H2 antigen; H-2D cell surface glycoprotein; H2-DC1-beta transplantation antigen pro

Entrez Gene ID

UniProt ID

Antigen Description

In the mouse the MHC Class 1 loci are called H2K, H2L and H2D. The equivalent loci in the human MHC are HLA (Human Leukocyte Antigen). MHC class I molecules are heterodimers, consisting of a single transmembrane polypeptide chain (the a-chain) which is highly polymorphic, and the invariant β2 microglobulin (which is encoded elsewhere, not in the MHC). MHC class I molecules are found on almost every nucleated cell of the body. Their major function is to present peptide fragments derived from antigens to cytotoxic T cells.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem;