Anti-MGST1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

MGST1 (AAH05923, 1 a.a. ~ 155 a.a) full-length recombinant protein with GST tag. The sequence is MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL

Conjugate

Alternative Names

MGST1; microsomal glutathione S-transferase 1; MGST; GST12; MGST-I; microsomal GST-1; microsomal GST-I; glutathione S-transferase 12;

Entrez Gene ID

UniProt ID

Antigen Description

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene.

Pathway

Biological oxidations; Chemical carcinogenesis; Drug metabolism - cytochrome P450; Glutathione metabolism