Specifications
Species Reactivity
Human; Monkey
Immunogen
Recombinant full length Human RNF156 produced in HEK293T cells (NP_056061).
Applications
Application Notes
WB: 1/500 - 1/2000; Flow Cyt: 1/100; ICC/IF: 1/100;
Target
Alternative Names
MGRN1; mahogunin ring finger 1, E3 ubiquitin protein ligase; mahogunin, ring finger 1; E3 ubiquitin-protein ligase MGRN1; KIAA0544; RNF156; RING finger protein 156; mahogunin RING finger protein 1; probable E3 ubiquitin-protein ligase MGRN1;
Product Background
Antigen Description
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem;
Citations
Publication ()
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COA
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