Anti-MGAT2 (aa 180-229) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A region within synthetic peptide: SIQLYPNEFP GSDPRDCPRD LPKNAALKLG CINAEYPDSF GHYREAKFSQ, corresponding to internal sequence amino acids 180-229 of Human MGAT2

Conjugate

Application Notes

WB: 1.25 μg/ml; IHC-P: 4 - 8 μg/ml;

Alternative Names

MGAT2; mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; GNT2; CDG2A; CDGS2; GNT-II; GLCNACTII; alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; glcNAc-T II; mannoside acetylglucosaminyltransferase 2; Beta

Entrez Gene ID

UniProt ID

Antigen Description

MGAT2 is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in its gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain.

Pathway

Asparagine N-linked glycosylation; N-Glycan biosynthesis; N-glycan antennae elongation in the medial/trans-Golgi; N-glycan biosynthesis, complex type