Rabbit Anti-Human METTL8 (a.a. 1-77) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human METTL8 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-77 aa of BC025250

Conjugate

Application Notes

WB: 1:500-1:3000
IF/ICC: 1:200-1:800

General Notes

This product (Catalog No. DPABH-12343) is a rabbit-derived polyclonal antibody raised against human METTL8, targeting the amino acid region 1–77 of the protein. It has been affinity purified by Protein A. METTL8 (methyltransferase-like protein 8) is an m3C methyltransferase that is best known for its mitochondrial role in installing m3C32 on mt-tRNAThr/Ser(UCN). METTL8 has proved to be a transcriptional target of STAT3 that mediates STAT3's functions in mESCs (PMID: 29706498). METTL8 has multiple splicing isoforms and can undergo sumoylation and associate with nuclear RNA-binding proteins to regulate R-loop formation on ribosomal DNA gene (presumably via its methyltransferase activity on m3C) (PMID: 38744809).
DPABH-12343 is suitable for use in Western blot (WB) (1:500–1:3,000), IF/ICC (1:200–1:800) applications.
DPABH-12343 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

methyltransferase like 8; METTL8

Entrez Gene ID

UniProt ID