Anti-MED10 polyclonal antibody (DPABH-00573)

Rabbit anti-Human MED10 (aa 1-100) polyclonal antibody for ICC/IF, WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human MED10.
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF:1/200; WB: 1 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MED10; mediator complex subunit 10; L6; NUT2; TRG20; mediator of RNA polymerase II transcription subunit 10
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MED10 (Mediator Complex Subunit 10) is a Protein Coding gene. Diseases associated with MED10 include neonatal abstinence syndrome and keratosis, seborrheic, somatic. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity. MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al. , 2003 [PubMed 12584197]).
Antigen Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The function about MED10 antigen include RNA polymerase II transcription cofactor activity.
Pathway
Developmental Biology; Gene Expression; Metabolism; PPARA activates gene expression.

Citations


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References


Kong, M; Mounier, C; et al. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis - Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 275:36035-36042(2000).
Sirotkin, AV; Dukesova, J; et al. Effect of growth factors on proliferation, apoptosis and protein kinase A expression in cultured porcine cumulus oophorus cells. REPRODUCTION NUTRITION DEVELOPMENT 42:35-43(2002).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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