Anti-ME2 monoclonal antibody, clone FQ8328

Antibody Isotype

IgG

Clone

FQ8328

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/250; IHC-P: 1/50 - 1/100; Flow Cyt: 1/100.

Alternative Names

ME2; malic enzyme 2, NAD(+)-dependent, mitochondrial; NAD-dependent malic enzyme, mitochondrial; NAD-ME; malate dehydrogenase; pyruvic-malic carboxylase; ODS1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Pathway

Pyruvate metabolism, organism-specific biosystem; Pyruvate metabolism, conserved biosystem; gluconeogenesis I, organism-specific biosystem;