Anti-MDH2 monoclonal antibody, clone 3G6BG9

Antibody Isotype

IgG1

Clone

3G6BG9

Species Reactivity

Mouse; Rat; Human; Pig

Immunogen

Tissue, cells or virus corresponding to Pig MDH2. Purified protein from porcine heart.

Conjugate

Application Notes

ICC/IF: 1 - 4 μg/ml; In-Cell ELISA: 4 μg/ml.

Alternative Names

MDH2; malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; mitochondrial malate dehydrogenase 2, NAD; MDH; MMDH;

Entrez Gene ID

Antigen Description

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

Pathway

Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, organism-specific biosystem; Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, conserved biosystem; Glyoxylate and dicarboxylate metabolism, organism-specific biosystem;