Anti-MCTS1 monoclonal antibody (DCABH-600)
Mouse anti-Human MCTS1 monoclonal antibody for WB
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Recombinant full length Human Malignant T cell amplified sequence 1 protein (NP_054779), produced in E. coli.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
MCTS1; malignant T cell amplified sequence 1; malignant T-cell-amplified sequence 1; MCT 1; multiple copies T-cell malignancies; malignant T cell-amplified sequence 1
Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. The function about MCTS1 antigen include RNA binding.
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GREENBERG, SJ; CHOI, Y; et al. PROFILE OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE GENE REPERTOIRES AND HIGHLY SELECTIVE DETECTION OF MALIGNANT CLONOTYPES IN ACUTE LYMPHOBLASTIC-LEUKEMIA. JOURNAL OF LEUKOCYTE BIOLOGY 57:856-864(1995).
GASTL, GA; ABRAMS, JS; et al. INTERLEUKIN-10 PRODUCTION BY HUMAN CARCINOMA CELL-LINES AND ITS RELATIONSHIP TO INTERLEUKIN-6 EXPRESSION. INTERNATIONAL JOURNAL OF CANCER 55:96-101(1993).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.