Anti-MCPH1 (aa 399-487) polyclonal antibody

Species Reactivity

Human

Immunogen

MCPH1 (NP_078872, 399 a.a. ~ 487 a.a) partial recombinant protein with GST tag. The sequence is ATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMK EAVGLKSTQNKGTTSKISNSSEGEAQSEH

Conjugate

Alternative Names

MCPH1; microcephalin 1; MCT; BRIT1; microcephalin; BRCT-repeat inhibitor of TERT expression 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.

Pathway

Cell Cycle; Condensation of Prophase Chromosomes; Mitotic Prophase;