Full length protein corresponding to Human ARHGEF14 aa 1-984. Isoform 4Sequence: MTVRRLSLLCRDLWALWLLLKAGADEIMHQDIVPLCAADIQDQLKKRFAY LSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFI LVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFK FNRDDFKMKVPVIMLSSVPDL
Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; GPCR downstream signaling; Neurotrophic factor-mediated Trk receptor signaling; Regulation of RhoA activity.
Citations
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