Full length protein corresponding to Human MCC aa 1-829.Sequence: MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLE KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQ GTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVA
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
MCC; mutated in colorectal cancers; colorectal mutant cancer protein; MCC1; FLJ38893; FLJ46755; DKFZp762O1615;
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Pathway
TNF-alpha/NF-kB Signaling Pathway;
Citations
Publication ()
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