Specifications
Immunogen
Recombinant fragment: ASTLQQLSFP VRAYKRLDGS TECCNNHSLT DVCFSYRNNF NKRLHTCLPA RKAVEATQVC RTNKDCKKSS SSSFCIIPSL ETHTRLIKVK HPPQIDMLYV GHPLHLH, corresponding to amino acids 312-419 of human MBTPS2 (NP_056968) with a tag
Target
Alternative Names
MBTPS2; membrane-bound transcription factor peptidase, site 2; membrane bound transcription factor protease, site 2; membrane-bound transcription factor site-2 protease; S2P; endopeptidase S2P; SREBPs intramembrane protease; membrane-bound transcription f
Product Background
Antigen Description
Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Pathway
Activation of Chaperones by ATF6-alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem; Unfolded Protein Response, organism-specific biosystem;
Citations
Publication ()
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COA
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