Anti-MATN4 polyclonal antibody (DPABH-23508)

Rabbit anti-Human MATN4 (N-terminal) polyclonal antibody for ICC/IF, WB, IHC-P Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
A 13 amino acid synthetic peptide near the N-terminus of Human Matrilin 4 (NP_085080).
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF: 20μg/ml; WB: 1 - 2μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MATN4; matrilin 4; matrilin-4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MATN4 (Matrilin 4) is a Protein Coding gene. Diseases associated with MATN4 include stromal dystrophy. Among its related pathways are Degradation of the extracellular matrix and Articular Cartilage Extracellular Matrix Pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MATN1. This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp complex. Alternative splicing results in multiple transcript variants.
Antigen Description
Major component of the extracellular matrix of cartilage. The function about MATN4 antigen include protein binding.
Pathway
ECM proteoglycans.

Citations


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References


Paakkonen, V; Vuoristo, JT; et al. Comparative gene expression profile analysis between native human odontoblasts and pulp tissue. INTERNATIONAL ENDODONTIC JOURNAL 41:117-127(2008).
Wagener, R; Kobbe, B; et al. Characterization of the mouse matrilin-4 gene: A 5 ' antiparallel overlap with the gene encoding the transcription factor RBP-L. GENOMICS 76:89-98(2001).

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