Anti-MATK monoclonal antibody, clone 0E8

Antibody Isotype

IgG1

Clone

0E8

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human MATK.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Flow Cytometry (1:200-1:400) & The optimal working dilution should be determined by the end user.

Alternative Names

MATK; megakaryocyte-associated tyrosine kinase; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK; megakaryocyte-associated tyrosine-protein kinase; protein kinase HYL; HYL tyrosine kinase; tyrosine kinase MATK; CSK homologous kinase; Csk-homologous kinase; tyrosylprotei

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Pathway

IL-3 Signaling Pathway; Kit Receptor Signaling Pathway; Neurotrophic factor-mediated Trk receptor signaling; Neurotrophin signaling pathway; Signal Transduction; Signaling by ERBB2; Signaling events mediated by Stem cell factor receptor (c-Kit);